Is the anti-aging NMN at the cellular level an IQ tax?

What is NMN? What does NMN do?

NMN is an inherent substance in the human body, also rich in some fruits and vegetables, it is widely involved in a number of biochemical reactions in the human body, is also the composition of NAD+ (nicotinamide adenine dinucleotide) raw material.

By supplementing NMN to improve the level of NAD+ in the body, so as to combat aging, that is to say, the function of NMN is mainly reflected by NAD+.

What does NAD+ have to do with aging?

To put it simply, NAD+ and aging are like fighting guerrilla warfare: you advance, I retreat, you retreat, I advance.

People with low NAD+ levels will become aging, and increasing NAD+ levels will delay aging.

Because of this, targeting the NAD+ metabolic pathway to increase NAD+ levels may be a potential means to improve age-related diseases and extend human lifespan and healthy lifespan.

How to supplement NMN daily?

Since NAD+ cannot absorbed orally, the level of NAD+ in the body can only increased by supplementing NAD+ precursor NMN.

There are two ways to supplement NMN in your daily life:

1. Food source

NMN widely distributed in everyday foods and occurs naturally in a variety of foods:

The NMN content in vegetables and fruits ranges from 0.25-1.88 mg /100 g, while raw beef and raw shrimp have relatively lower NMN content than plant foods (0.06-0.42 mg /100 g).

2. NMN supplement

There are many kinds of NAD+ precursors, of which NMN is the most direct precursor of NAD+, which is directly converted to NAD+ by the enzyme NMNAT.

Attention!

• The pharmacokinetics and metabolic mechanisms of NMN are still being studied, and not all cells can convert all NAD+ precursors to NAD+. Moreover, the degree of absorption and utilization of NAD+ precursors is also different in different tissues and organs.
• Regarding the side effects of NMN, studies have pointed out that doses as high as 1250mg/ day of NMN do not cause any adverse side effects or harm health.

Although NMN currently a commonly used product with anti-aging effect, if taken for a long time, the effective effect of NMN anti-aging should understood from a scientific point of view, and used under the guidance of professionals.

References:

• 1、Song, Q, et al., （2023). The Safety and Anti-Ageing Effects of Nicotinamide Mononucleotide in Human Clinical Trials: An Update. Advances in Nutrition.
• 2、Nadeeshani, H., Li, J., Ying, T., Zhang, B., & Lu, J. （2022). Nicotinamide mononucleotide （NMN) as an anti-aging health product–promises and safety concerns. Journal of advanced research, 37, 267-278.
• 3、Fukamizu Y, et al., Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult people of all genders. Sci Rep. 2022;12:14442. doi:10.1038/s41598-022-18272-y.