
Glutathione promotes T cell metabolism, which leads to inflammation
abstract Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidant glutathione (GSH) response, which is essential for buffering elevated ROS and preventing cell damage. We report that glutathione is essential for T cell effector function by regulating metabolic activity. Conditional gene knockout of the catalytic subunit of glutamate-cysteine ligase (Gclc) blocks glutathione…