Glutathione
If NAC, glycine and the like are the “powerful assistants of superheroes”, then glutathione is the “superhero” within the cell itself.
Glutathione is hailed as the “King of Antioxidants” or “Master Antioxidant”, and it is the most important and powerful endogenous antioxidant in the human body.
What is glutathione?
Glutathione is a tripeptide molecule composed of three amino acids – glutamic acid, cysteine and glycine.
Glutathione is present in every cell of the body, especially in the liver where its concentration is very high.
The uniqueness of glutathione lies in the fact that it can not only “take the lead” in neutralizing free radicals but also act as the “chief commander” to regenerate other antioxidants (such as vitamin C and vitamin E), restoring their combat effectiveness.
core functions and roles of glutathione
1. Powerful antioxidant effect
Directly neutralize free radicals and reactive oxygen species to protect cells from damage caused by oxidative stress.
Oxidative stress is the root cause of aging and many chronic diseases.
2. key to liver detoxification:
Glutathione is the core substance of the liver’s Phase II detoxification pathway.
Glutathione can combine with toxins, heavy metals, drug by-products, etc., turning them into water-soluble substances, which are then excreted from the body through bile or urine.
3. Immune system regulation
Glutathione optimizes the function of immune cells and helps the body effectively combat infections and diseases.
It can not only enhance the immune response but also prevent the immune system from being overly activated when necessary (” cytokine storm “).
4. Cellular energy production
Mitochondria are the “energy factories” of cells. Glutathione is crucial for protecting mitochondria from oxidative damage and maintaining their efficient operation.
5. Metabolism and Anti-aging
Glutathione levels naturally decline with age.
Maintaining a high level is associated with a healthier aging process, better energy and clearer thinking.
6. Skin Whitening and health
Glutathione can inhibit the activity of tyrosinase and interfere with the production of melanin, and thus is used as an ingredient for “whitening and brightening the skin” in the field of skin care.
Its antioxidant capacity also helps protect the skin from ultraviolet damage.
Why is it necessary to pay attention to glutathione levels?
Many modern lifestyle factors consume glutathione in the body:
- Chronic stress
- Environmental pollution and toxin exposure
- Malnutrition
- Infection
- Aging
- Excessive exercise
- Staying up late and lack of sleep
How to increase the level of glutathione?
This is the most crucial part, and there are mainly three strategies
1. Supplement “precursor substances” (most effective and commonly used strategy)
The body needs raw materials to synthesize glutathione.
Supplementing the following substances can effectively enhance its level:
- ①N-acetylcysteine: This is the most important precursor, directly providing the cysteine necessary for the synthesis of glutathione, which is usually insufficiently supplied.
- ② Glycine: Another key amino acid.
- ③ α -lipoic acid: It helps to regenerate the oxidized glutathione.
- ④ Methyl donors: such as vitamin B6, B12, and betaine, support the synthesis process of glutathione.
- ⑤ Foods rich in sulfur: garlic, Onions, cruciferous vegetables (broccoli, kale), etc., can provide compounds that support the synthesis of glutathione.
2. Directly supplement glutathione
In the past, it believed that oral glutathione would digested and decomposed, with a low absorption rate.
However, there is now evidence suggesting that, especially by using special forms such as liposomes or S-acetylglutathione, its bioavailability can be enhanced and it can be directly absorbed and utilized.
3. Promote the body’s own synthesis
- Regular exercise (moderate rather than excessive)
- Get enough sleep
- A healthy diet rich in fruits and vegetables
form of glutathione supplements
- Oral capsules/tablets: The most common, but liposomal glutathione or S-acetylglutathione should be selected to enhance absorption rate.
- Intravenous injection: Performed by doctors in hospitals, it can directly enter the bloodstream and has the strongest efficacy. It is often used in the treatment of certain specific diseases.
- Inhalation type: Used for respiratory system diseases.
- External skin care: Added to serums and face creams for whitening and anti-oxidation.
Summary of potential benefits and uses of glutathione
- Improve liver health (fatty liver, detoxification)
- Anti-aging and vitality enhancement
- Improve skin condition (whitening, fading spots, anti-acne)
- Support the immune system
- Improve insulin resistance
- Support brain health (may have a positive impact on Parkinson’s disease and Alzheimer’s disease)
- Reduce inflammation
Suggestion
Give priority to lifestyle and nutrition
Make sure your diet is rich in precursors (eat more broccoli, garlic, Onions, and high-quality protein), ensure adequate sleep, and engage in moderate exercise.
Consider “precursor supplementation” :
If you want to improve your level through supplements, NAC is usually the most cost-effective and well-supported option. Glycine is also a very good supplement.
Direct supplementary options:
If you have clear whitening or specific health needs, you can consider liposomes or S-acetylglutathione and choose a brand with a good reputation.
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